nkhani

Ngakhale Iniparib ali ndi mbiri yabwino yolephera, PARP inhibitors abwerera ku bwalo la khansa ya m'mawere atadutsa chotchinga cha khansa ya ovarian, ndi Olaparib ndi Talazoparib akuchita bwino pa chithandizo chamankhwala amodzi kwa odwala omwe ali ndi matenda apamwamba a metastatic [2-3].

Komabe, mu khansa ya m'mawere, PARP inhibitors amakonda kulimbana ndi khansa ya m'mawere yakupha kwambiri katatu, yomwe ndi mtundu wofala kwambiri wa odwala omwe ali ndi vuto la BRCA1.Ngakhale chithandizo chamankhwala amodzi chikhoza kukhala chopambana, kodi mphamvu yake imakula?

Niraparib, yemwe akuchulukirachulukira wa PARP inhibitors, ndi umboni wa izi.Zotsatira zoyambirira kuchokera ku mayeso a TOPACIO/KEYNOTE 162 zidawonetsa kuti Niraparib kuphatikiza Pembrozulimab (K) zidapangitsa kuti 29% ya odwala omwe ali ndi khansa ya m'mawere yopanda katatu, ndipo osati kwa odwala omwe ali ndi vuto la majini a brca1/2 [4].

Zotsatira za machitidwe osiyanasiyana a pharmacological pa mphamvu ya mankhwala osiyanasiyana zimawonekeranso mu kufufuza kwachipatala polimbana ndi khansa ya m'mawere.Mwachitsanzo, Talazoparib ndi Veliparib onse ndi opambana komanso osachita bwino munjira yomweyo ya neoadjuvant [5].Choncho, pochiza khansa ya m'mawere, yemwe amaseka komaliza amaseka kwambiri.
Inde, PARP inhibitors sayenera kupindulitsa amayi okha, komanso kufanana pakati pa amuna ndi akazi.


Nthawi yotumiza: May-28-2020